Immunological tolerance
The Damo Lab has developed novel engineered mouse models that allow the study of the mechanisms of peripheral tolerance in endogenous T cells and facilitate the translation of such mechanisms into immuno-modulatory therapies.
The Damo Lab has developed novel engineered mouse models that allow the study of the mechanisms of peripheral tolerance in endogenous T cells and facilitate the translation of such mechanisms into immuno-modulatory therapies.
Immune-related Adverse Events of checkpoint receptor blockade immunotherapy
The Damo Lab studies the role of T cells in the pathogenesis of immune-related Adverse Events (irAEs) in skin and colon. Our goal is to propose therapeutic approaches that prevent irAEs without interfering with the effectiveness of anti-cancer immunity.
The Damo Lab studies the role of T cells in the pathogenesis of immune-related Adverse Events (irAEs) in skin and colon. Our goal is to propose therapeutic approaches that prevent irAEs without interfering with the effectiveness of anti-cancer immunity.
Self-tolerance in cancer disease
The Damo Lab utilizes sophisticated mouse models of cancer to investigate the behavior of T cells specific for either self-antigens or neo-antigens expressed by cancer cells and develop approaches to improve the benefits of cancer immunotherapy.
The Damo Lab utilizes sophisticated mouse models of cancer to investigate the behavior of T cells specific for either self-antigens or neo-antigens expressed by cancer cells and develop approaches to improve the benefits of cancer immunotherapy.